Sickle Cell Disease and Older Patients

What is Sickle Cell Disease?

Sickle cell disease affects approximately five million people worldwide and is one of the most common inherited blood disorders. Its complications include leg ulcers, Splenic crisis, and hemolysis. In this article, we will explore the treatment options for sickle cell disease and its complications. In addition, we will discuss how to recognize the symptoms. This article also explores the challenges faced by older patients with sickle cell disease. Ultimately, this information will improve care for patients with sickle cell disease.

Hemoglobin S

When hemoglobin S is over-produced, a process called vesicle formation occurs. Phosphatidylserine is found in the outer leaflet and has a clotting factor catalyzing effect. Hemoglobin S interacts with the cell membrane. It also binds with the very late antigen-4 (VCAM-1) and vascular cell adhesive molecule-1 (VCAM-1). When exposed to hypoxia, these two proteins interact, which may contribute to the increased rigidity of the membrane.

The United States requires newborn screening for sickle cell trait, a genetic disorder affecting a person’s hemoglobin composition. In addition to sickle cell screening, sickle prep can also detect abnormal hemoglobin S. Hemoglobin electrophoresis can confirm the diagnosis. The test gives a percentage of the hemoglobin types. Symptoms and complications can be treated with appropriate treatment.

Splenic crisis

Splenic crisis in sickle cell disease is a life-threatening complication of this anemia. Fortunately, mortality rates have decreased since the introduction of screening programs, vaccinations, and parental education. While the acute splenic sequestration crisis can be fatal, effective management of the condition is based on rapidly correcting the hypovolemic state and administering crystalloids or packed red cells. There are no established international guidelines on the management of splenic crises. In patients with two or more such crises, splenectomy is generally recommended.

The risk of splenic crises increases with age, and patients with SCD may need to undergo surgery. This is particularly important for children, as the spleen is at risk of having another episode in the future. Some children may also require splenectomy for this reason. Depending on the cause of the spleen crisis, the Sickle Cell team may recommend this option for patients with the disease.

Leg ulcers

In addition to their severe pain, leg ulcers caused by sickle cell disease can severely compromise the quality of life. In fact, the occurrence of these ulcers is highly correlated with geographic origin. It has been estimated that up to 18% of people with SCD will develop these ulcers during their lifetime. Affected individuals often experience difficulty healing these ulcers, and they significantly affect the quality of life of those living with SCD.

The pathophysiology of leg ulcers due to sickle cell disease is poorly understood, and its role in the development of these lesions remains unclear. The role of nitric oxide pathways and inflammation in the development of leg ulcers is unknown. In this study, we examined the relationship between inflammatory cytokines and nitric oxide metabolites in patients with SCD. We have now found that the inflammatory molecules found in leg ulcers caused by SCD are related to the formation of these wounds.


Regular medical checkups for the treatment of sickle cell anemia are essential to prevent severe complications. It is also important to build a relationship with your healthcare provider. You may experience anxiety or depression related to your condition, but your healthcare provider is available to help you overcome these issues. Your healthcare provider can refer you to resources to learn more about your disease and educate your peers about it. Here are some tips to deal with the stigma associated with sickle cell anemia.

The myeloablative conditioning regimen has high success rates, but is too toxic for many adult patients with organ dysfunction. However, there is hope that treatment of sickle cell anemia can reverse the disease without replacing bone marrow. In this case, less intense conditioning regimens have been developed. The donor can be an HbAA or a chimeron that is 20% chimeron. After a year or so, the condition is usually under control and the patient can return to their normal life.

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